PDF | Virosomes are reconstituted viral envelopes that can fill in as vaccines and as vehicles for cell conveyance of different macromolecules. PDF | As from the last eras number of the revolution in the drug delivery Virosomes denotes such a unique system for presentation of antigen. ABSTRACT. Virosomes are reconstituted viral envelopes that can serve as vaccines and as vehicles for cellular delivery of various macromolecules.
|Language:||English, Spanish, Hindi|
|Genre:||Politics & Laws|
|Distribution:||Free* [*Sign up for free]|
Virosomes are reconstituted viral envelopes that can fill in as vaccines and as The prospect of drug delivery and targeting systems utilizing virosomes is an. virus-like particle (VLP) vaccine technology, called virosomes, and their prospect of drug delivery and targeting using virosomes is an. review, we will discuss influenza virosomes as a versatile delivery system for molecules in vivo and a list of so far tested applications of virosomes as carrier of.
Thorne, T. Hwang, W. O'Gorman et al. Earp, S. Delos, H. Park, and J. Marsh, Ed. View at Google Scholar J. Almeida, D. Edwards, C.
Brand, and T. View at Google Scholar R. Yamada, Y. Iwasaki, H. Tada et al. Cornet, M. Vandenbranden, J. Cogniaux, L. Giurgea, D. Dekegel, and J. Kapczynski and T. Uchida, J. Kim, M. Yamaizumi, Y. Miyake, and Y. Kaneda, T. Nakajima, T. Nishikawa et al.
Felnerova, J. Viret, R. Lund, R. Hunt, M. Gottesman, and C. Moser, I. Metcalfe, and J. Suarez and S. Noda and Y. Skehel and D.
Fukuyama and Y. Cross, L. Burleigh, and D. Yoshimura, K. Kuroda, K. Kawasaki, S. Yamashina, T.
Maeda, and S. Bron, A. Ortiz, J. Dijkstra, T. Stegmann, and J. Duzgunees, Ed. View at Google Scholar T. Stegmann, H. Morselt, F. Booy, J. Scherphof, and J. Ortiz, and J. Mischler, B. Finkel, J. Que, B.
Scarpa, and S. Cryz Jr. Mischler and I. B17—B23, Zurbriggen and R. Zurbriggen, I. Novak-Hofer, A. Seelig, and R. Zurbriggen, A.
Helg et al. Correale, M. Cusi, M. Sabatino et al. Terrosi et al. Yang and J. Schoenberger, R. Toes, E. Offringa, and C. Bungener, K.
Serre, L. Bijl et al. Angel, L. Chaperot, J. Molens et al. Renieri et al. Mastrobattista, P. Schoen, J. Wilschut, D. Crommelin, and G. Schoen, L.
Leserman, and J. Waelti, N. Wegmann, R. Schwaninger et al. Jamali, M. Holtrop, A. Wiedermann, C. Wiltschke, J.
Jasinska et al. Curran and D. Duzgunes, Ed. Takimoto, G. Various cancer gene therapy methods have been reported, such as adoptive immunotherapy using ex vivo gene transfer to immune cells [ 19 ], intratumoral injection of cytokine genes [ 20 ], suicide gene therapy using the herpes virus thymidine kinase gene [ 21 ], and intratumoral injection of the p53 gene [ 22 ].
To achieve high gene expression, viral vectors such as retrovirus and adenovirus vectors have been utilized. However, in general, cancer gene therapy has not had satisfactory therapeutic effects. Therefore, to enhance the cancer-cell-killing effect, viruses that replicate mainly in cancer cells have been used for treatment [ 23 ].
Various types of oncolytic viruses have been developed by isolating viruses with inherent tumor selectivity [ 24 , 25 ] and by engineering recombinant viruses [ 26 , 27 ]. Furthermore, the combination of an oncolytic virus and gene therapy has been applied for cancer treatment, such as vaccinia virus including the GM-CSF gene [ 28 ].
Although these oncolytic viral treatments exhibited a strong therapeutic effect, safety might be a problem because the virus with an intact genome still exists in noncancerous cells [ 29 ]. An inactive virus that did not have the ability to amplify its progeny virus in host cells has also been used as a high-safety delivery vector for drugs and plasmids in cancer therapy.
In particular, enveloped-virus-derived vectors have attracted attention because enveloped-vector-delivered molecules can escape endosomal degradation by direct introduction to the cytoplasm via membrane fusion [ 30 ]. A vector derived from an inactive enveloped virus is called a virosome, which is now an all-inclusive term for a reconstituted envelope that contains viral envelope proteins Figure 1 a or viral envelope particles Figure 1 b [ 31 ].
Several types of virosomes have been generated, for example, virosomes based on influenza virus [ 32 ], hepatitis B virus [ 33 ], human immunodeficiency virus [ 34 ], Newcastle disease virus [ 35 ], and Sendai virus [ 36 , 37 ]. Harris J. Trends Genet. PubMed Google Scholar 6. Bagai S. PubMed Google Scholar 7. FEBS Lett. Ramani K. USA 95, — PubMed Google Scholar Sambrook J. Google Scholar Celis J.